Overview
Opioids assist individuals discover aid from ache, whether or not brought on by surgical procedure or from a power situation, however they’ve the potential to be abused or result in harmful illicit medicine. This has created a disaster that has a big affect on our international society. A 2015 report from the White Home Council of Financial Advisers estimated that the opioid disaster price the U.S. economic system over US$500 billion. The disaster has gotten worse. A latest 500-page congressional report estimated that opioid-related deaths now price US$1 trillion yearly, roughly 4.3 % of the nation’s GDP. A complementary report from the U.S. Middle for Illness Prevention (CDC) contains nonfatal accidents and estimates the price to be US$4.2 trillion. Wanting past the US, the World Well being Group estimates that 500,000 individuals die per yr because of drug overdose, and 70 % of these deaths are brought on by opioids.
What may be executed to fight the opioid disaster? It’s a fancy downside, with governments, researchers, and docs all looking for the reply. Remedy is one reply to combatting this disaster, ideally serving to opioid addicts return to a life that’s free from drug abuse. But remedy for opioid habit sometimes consists of detoxing, psychotherapy and changing the issue opioid with a weaker opioid, corresponding to methadone or buprenorphine. Whereas this routine could assist some customers get better, one research discovered that 91 % of addicts will relapse after remedy. We’d like simpler remedy to really fight the disaster.
Psychedelics have emerged as a promising remedy for opioid habit, together with exhibiting potential for treating alcohol use dysfunction and even despair. Ketamine, recognized for its position in anesthesia, could also be an efficient remedy for alcohol use dysfunction. Psilocybin, the energetic ingredient in psychedelic mushrooms, reveals promise for treating despair. Ibogaine, which is discovered primarily within the roots of the Iboga plant, could assist opioid addicts get better from their habit and supply a non-opioid alternative for ache aid. Nonetheless, every psychedelic wants additional analysis and growth to develop into a very therapeutic treatment that may be legally utilized in remedy.
Nirvana Life Sciences (CSE:NIRV) was based to develop novel therapeutic merchandise derived from psychedelics. The corporate believes that naturally sourced psychedelics utilized in distinctive formulations can ship non-addictive options that help in opioid habit remedy and ongoing ache administration. Nirvana Life Sciences is concentrated strictly on creating efficient merchandise, moderately than providing wellness retreats or clinics like a few of their rivals.
The corporate has focused two merchandise for its first growth part. One product will deal with transitioning from opioids to non-addictive ache aid therapies and ideally prevents relapse. The second product will present non-addictive ache aid. Nirvana Life Sciences started by buying the mental property (IP) behind these formulations and has since performed its personal analysis to advance them.
How is the corporate doing this legally? The usage of psychedelics in normal medicinal therapies is a brand new frontier, and as such, Nirvana Life Sciences is taking each precaution towards authorized issues and even contemplating the curiosity criminals could have in its services. It has acquired a Part 56 Exemption from Well being Canada, enabling them to legally conduct its analysis and growth in Vancouver. Moreover, its new facility shall be constructed to Degree 9 Safety Requirements to safeguard its analysis. The corporate can be pursuing a Vendor’s License from Well being Canada to permit for the motion of supplies between licensees. The tip objective is to introduce FDA-approved drugs for widespread utilization.
Pre-clinical analysis for its formulations have already begun. This analysis is being undertaken on the College of Camerino in Italy. This lab was granted particular permission from the Italian authorities to work with psilocybin-based compounds. Studies from these trials are anticipated in Q3 2022.
Nirvana Life Sciences is led by visionaries and docs working collectively to totally develop these probably revolutionary drugs. Bruce Clark, CEO, is motivated by discovering new options to complicated societal points and has 30 years of expertise managing modern corporations. Dr. Sazzad Hossain, CSO, has served on main Canadian bio pharmaceutical corporations and is taken into account a drug discovery chief. Robert August, head of innovation, is an academically educated chemist who’s revered within the psychedelic neighborhood and is a powerful advocate for ending prohibition.
Michael McCune, Vice President of Operations, has years of expertise within the extraction area.. Connie Cling, CFO, has over 20 years of expertise in accounting and administration, together with working with overseas and home corporations. The corporate has attracted a formidable workforce of researchers together with Dr. Massimo Nabissi and Dr. Naseem Gaur.
Firm Highlights
- Nirvana Life Sciences is an modern analysis and growth firm targeted on novel formulations for opioid habit and ache administration that use psychedelic compounds.
- The corporate is solely targeted on merchandise, moderately than wellness retreats or psychotherapy packages like a few of its rivals.
- Nirvana Life Sciences’ first part of growth is focusing on two merchandise, one to assist in opioid habit restoration and the opposite is focusing on non-addictive ache administration.
- IP has been bought from researchers who’ve extensively studied the results of psychedelic compounds for medicinal functions
- The corporate is taking each precaution to function legally and defend towards potential prison components which will goal its services
- Pre-clinical analysis started in 2021 and the outcomes are anticipated in Q3 2022 and can decide future developments
- A powerful workforce of docs and visionaries lead the corporate, every bringing their specialty to the corporate to totally develop its merchandise
Key Merchandise
Remedy for Opioid Habit
The corporate has formulated a product that assists within the transition from opioids to non-addictive ache aid. A lot of Nirvana Life Sciences’ focus is on creating and refining this product, because it paves the way in which for its second product which might function a standalone product for these hooked on opioids to return to an opioid-free life.
Undertaking Highlights:
- Formulated to Forestall Abuse: The energetic ingredient can solely be launched when taken orally, making IV or insufflation ineffective because the energetic ingredient is not going to be launched.
- Prioritizing Pure Supplies Over Artificial Replacements: Most rivals intention to develop artificial psychedelics, whereas Nirvana Life Sciences is concentrated on perfecting a scalable course of that extracts the specified compounds from pure sources, corresponding to mushrooms. The corporate should use artificial options if required.
- Unique License to Proprietary Extraction Expertise: The corporate has secured a license that provides it unique entry to extraction expertise that may assist scale the manufacturing of its drugs, often known as PureAI Distillation.
Remedy for Non-Addictive Ache Administration
Many individuals who develop opioid habit nonetheless want ache administration therapies. The corporate’s second product goals to offer ache aid with out creating a brand new habit. Psychedelic compounds have inherent ache aid properties which were remoted to be used because the energetic ingredient on this product.
Undertaking Highlights:
- Solely Efficient Orally: Identical to the habit remedy product, the corporate’s ache administration treatment will solely be efficient when taken orally.
- Artificial Extraction Could Show Viable: The contracted analysis facility in New Delhi has undertaken a novel course of for producing artificial psilocybin supplies at scale.
- At the moment Present process Preclinical Analysis: The corporate’s formulations are present process pre-clinical analysis with outcomes anticipated in Q3 2022.
Administration Group
Bruce Clark – Chief Govt Officer
Bruce Clark leads the Nirvana workforce, in search of new options to considered one of our society’s most confounding points. He sees nice potential within the alternatives for the event of latest approaches to a fancy downside that’s each a public well being and financial subject for our communities. Clark is a confirmed innovator who brings 30 years of administration expertise throughout quite a lot of industries, together with vitality, meals and beverage manufacturing and life science. He possesses broad expertise in product growth, manufacturing and product distribution and a transparent understanding of the regulatory course of. He has a deep understanding of the general public coverage points at play and the significance of collaboration with all ranges of presidency and well being professionals by the event course of.
Connie Cling – Chief Monetary Officer
Connie Cling has over 20 years of finance, accounting, and administration expertise in quite a lot of industries, together with vitality, mining, and well being science. Up to now 12 years, Cling has acted as an advisor, officer and director for numerous private and non-private corporations, which embody Canadian-based corporations to foreign-controlled entities. From 1999 to 2009, Cling labored in skilled accounting companies and held senior positions in tax and audit practices. Having served over 40 public- and private-companies, she has gained in-depth data of monetary and regulatory affairs. Cling’s expertise in coping with individuals from totally different cultures and disciplines has solidified her skill to know the wants of stakeholders and talk complicated concepts. Cling is a Member of the Chartered Skilled Accountants of Canada and British Columbia and holds a bachelor of accounting science from the College of Calgary.
Dr. Sazzad Hossain – Chief Scientific Officer
Dr. Sazzad Hossain is the previous chief scientific officer of InMed Prescribed drugs, a number one public Canadian biopharmaceutical firm. Beforehand he labored as a senior scientist on the Biotechnology Analysis Institute of Nationwide Analysis Council Canada. Dr. Hossain is a drug discovery chief with over 15 years of biotech and pharmaceutical expertise with small molecules and biologics in a number of illness indications. He has expertise in accelerated drug discovery and commercialization processes with mixed expertise in preclinical in vivo pharmacology, drug metabolism and pharmacokinetics (DMPK), security and toxicology. He has led groups within the strategic design of latest pure well being merchandise and generated a whole lot of thousands and thousands of {dollars} in income by main the event of a number of profitable compounds. Dr. Hossain holds a PhD in biology and was a postdoctoral fellow on the Centre for Molecular Medicines and Therapeutics on the College of BC.
Robert August – Head of Innovation
Robert August holds a grasp’s of science diploma and is an academically educated medicinal chemist with a deal with ergolines, phenethylamines and tryptamines. August started his educational profession at Loyola College in Baltimore, Maryland. Throughout his undergraduate years, he labored as an analytical chemist for Martel Laboratories the place he acquired his state analytical certifications for elevated intracranial strain (ICP), gasoline chromatography–mass spectrometry (GCMS) and liquid chromatography with tandem mass spectrometry (LCMS) operations.
Whereas pursuing a postgraduate diploma in medicinal chemistry at Johns Hopkins College, he turned his focus towards the synthesis of psychoactive and psychedelic compounds, particularly ergolines corresponding to LSD and phenethylamines like MDMA and 2CB. Round this time, August started to work as a analysis chemist; and, finally, started to actively pursue working partnerships with different chemists who had been researching psychedelic compounds like Dr. David E. Nichols and Nick Sand, with whom August labored briefly in Vancouver, BC. After incomes a fame as a talented chemist, he was invited to work alongside Ben Alkire at Purdue College in Lafayette, Indiana, the place he went on to cofound Berkeley-Clearlight Analysis (BCRG). Whereas forming BCRG, August acquired limitless entry to the D.E. Nichols Archive at Purdue College and the huge array of synthesis notes created by Dr. Oberlender throughout his time as a chemist for the Nichols’ workforce. Within the years that adopted, August synthesized quite a few novel compounds and analysis chemical compounds, turning into the primary individual to synthesize 3,4-MDMA Monohydrate HCl as a crystalline strong and as a beta ketone. August is a extremely revered member of the psychedelic neighborhood and an advocate for ending prohibition.
Michael McCune – Vice President Operations
Michael McCune is a seasoned entrepreneur and innovator within the extraction area. Since 2013, he has utilized his ardour for science to creating novel processes for producing energetic pharmaceutical substances (API) for the hashish business. He has constructed a specialty for at-scale extraction of all kinds of supplies. McCune led the event of a modern distillation system that provides important operational benefits and automation. He has overseen the event, trials and contract manufacture of this method. McCune is acknowledged as a frontrunner in these applied sciences and has co-authored a number of patents. He maintains a worldwide community and has introduced at quite a few conferences on the subjects of extraction and hashish applied sciences.
